Anatomical Wiring and Functional Networking Changes in the Visual System Following Optic Neuritis.

ABSTRACT:

Importance

Clinical outcome in multiple sclerosis was suggested to be driven by not only remyelination but also adaptive reorganization. This mechanism needs to be further understood.

Objective

To explore anatomical and functional visual networks in patients with optic neuritis (ON) to assess the relative weight of each connectivity modality to expedite visual recovery.

Design, setting, and participants

Between March 11, 2011, and May 26, 2014, 39 patients with either clinically isolated syndrome (CIS) ON (n = 18) or other CIS (non-ON) (n = 21) were recruited 1 to 28 months following an initial clinical event. These patients enrolled in an ongoing prospective cohort study (107 participants at the time of this present study) about the disease course of CIS and multiple

SUBMITTER: Backner Y 

PROVIDER: S-EPMC5885861 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature