Histopathological and Inflammatory Features of Chronically Discharging Open Mastoid Cavities: Secondary Analysis of a Randomized Clinical Trial.

ABSTRACT:

Importance

Many patients with an open radical mastoid cavity experience therapy-resistant otorrhea. Little is known about the underlying histopathological substrate of unstable cavities and the correlation with treatment failure.

Objective

To study the histopathological and inflammatory features of chronically discharging open radical mastoid cavities and the influence of different treatments.

Design, setting, and participants

This secondary analysis of a randomized clinical trial was a histopathology study of tissue samples of a cohort of 30 patients with a chronically discharging open mastoid cavity. Samples were taken from the cavities, which were treated with either honey gel or conventional eardrops in a tertiary center between 2012 and 2013. Tissue staining was

SUBMITTER: Henatsch D 

PROVIDER: S-EPMC5885876 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature