Comparative Evaluation of Clinical Methods of Tear Film Stability Assessment: A Randomized Crossover Trial.

ABSTRACT: Importance:Tear film breakup time assessment is an integral component of dry eye evaluation. To our knowledge, the comparative discriminative ability of the noninvasive Keratograph (Oculus) vs conventional fluorescein method in detecting dry eye is unknown. Objective:To compare tear film stability measurements obtained with an automated noninvasive corneal topographer vs conventional fluorescein methods and evaluate their respective discriminative ability in detecting dry eye. Design, Setting, and Participants:This investigator-masked randomized crossover trial was conducted at a single-center university clinic between May 26, 2016, and October 3, 2016, and included 74 participants 18 years or older. Participants were recruited into 2 equally sized age, sex, and race/ethnicity-matched grou

SUBMITTER: Wang MTM 

PROVIDER: S-EPMC5885903 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature