Web Platform vs In-Person Genetic Counselor for Return of Carrier Results From Exome Sequencing: A Randomized Clinical Trial.

ABSTRACT:

Importance

A critical bottleneck in clinical genomics is the mismatch between large volumes of results and the availability of knowledgeable professionals to return them.

Objective

To test whether a web-based platform is noninferior to a genetic counselor for educating patients about their carrier results from exome sequencing.

Design, setting, and participants

A randomized noninferiority trial conducted in a longitudinal sequencing cohort at the National Institutes of Health from February 5, 2014, to December 16, 2016, was used to compare the web-based platform with a genetic counselor. Among the 571 eligible participants, 1 to 7 heterozygous variants were identified in genes that cause a phenotype that is recessively inherited. Surveys were administered after cohort

SUBMITTER: Biesecker BB 

PROVIDER: S-EPMC5885925 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature