Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents.

ABSTRACT:

Importance

Many mental disorders emerge during adolescence, which may reflect a cost of the potential for brain plasticity offered during this period. Brain dysconnectivity has been proposed as a common factor across diagnostic categories.

Objective

To investigate the hypothesis that brain dysconnectivity is a transdiagnostic phenotype in adolescence with increased susceptibility and symptoms of psychiatric disease.

Design, setting, and participants

We investigated clinical symptoms as well as cognitive function in 6487 individuals aged 8 to 21 years from November 1, 2009, to November 30, 2011, in the Philadelphia Neurodevelopmental Cohort and analyzed diffusion magnetic resonance imaging brain scans for 748 of the participants.

Main outcomes and measures

Indep

SUBMITTER: Alnæs D 

PROVIDER: S-EPMC5885956 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature