Persistent, generalized hypersensitivity of olfactory bulb interneurons after olfactory fear generalization.

ABSTRACT: Generalization of fear from previously threatening stimuli to novel but related stimuli can be beneficial, but if fear overgeneralizes to inappropriate situations it can produce maladaptive behaviors and contribute to pathological anxiety. Appropriate fear learning can selectively facilitate early sensory processing of threat-predictive stimuli, but it is unknown if fear generalization has similarly generalized neurosensory consequences. We performed in vivo optical neurophysiology to visualize odor-evoked neural activity in populations of periglomerular interneurons in the olfactory bulb 1 day before, 1 day after, and 1 month after each mouse underwent an olfactory fear conditioning paradigm designed to promote generalized fear of odors. Behavioral and neurophysiological changes were asse

SUBMITTER: Kass MD 

PROVIDER: S-EPMC5886010 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature