Mid-gestational changes in cervicovaginal fluid cytokine levels in asymptomatic pregnant women are predictive markers of inflammation-associated spontaneous preterm birth.

ABSTRACT:

Objectives

Perturbation of the choriodecidual space before the onset of spontaneous preterm birth (sPTB) could lead to a concomitant rise in both cervicovaginal fluid (CVF) cytokine and fetal fibronectin (FFN), and assessing the concentrations of both markers could improve the prediction of sPTB (delivery before 37 completed weeks of gestation). Therefore, we prospectively determined mid-trimester changes in CVF cytokine and FFN concentrations, and their predictive capacity for sPTB in asymptomatic pregnant women.

Study design

CVF collected at 20⁺⁰-22⁺⁶ weeks (n = 47: Preterm-delivered = 22, Term-delivered = 25) and 26⁺⁰-28⁺⁶ weeks (n = 50: Preterm-delivered = 17, Term-delivered = 33) from 63 asymptomatic pregnant women at risk of

SUBMITTER: Amabebe E 

PROVIDER: S-EPMC5886036 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature