Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease.

ABSTRACT: Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene (htt). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby preventing or facilitating transcription. Although protein acetylation has been found to affect HD symptoms, little is known about the potential role of protein methylation in HD pathology. In recent years, a series of proteins have been described that are responsible for methylating and demethylating histones as well as other proteins. We carried out systematic genetic interaction studies testing lysine and arginine methylases and demethylases in a Drosophila melanogaster HD model. We found that mo

SUBMITTER: Song W 

PROVIDER: S-EPMC5886221 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature