Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish.

ABSTRACT: Mechanisms generating diverse cell types from multipotent progenitors are fundamental for normal development. Pigment cells are derived from multipotent neural crest cells and their diversity in teleosts provides an excellent model for studying mechanisms controlling fate specification of distinct cell types. Zebrafish have three types of pigment cells (melanocytes, iridophores and xanthophores) while medaka have four (three shared with zebrafish, plus leucophores), raising questions about how conserved mechanisms of fate specification of each pigment cell type are in these fish. We have previously shown that the Sry-related transcription factor Sox10 is crucial for fate specification of pigment cells in zebrafish, and that Sox5 promotes xanthophores and represses leucophores in a shared x

SUBMITTER: Nagao Y 

PROVIDER: S-EPMC5886393 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature