DIVA metabolomics: Differentiating vaccination status following viral challenge using metabolomic profiles.

ABSTRACT: Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by the authors has established the potential for metabolomic profiling to reveal metabolites associated with systemic immune responses to vaccination. The current study builds on this work by demonstrating for the first time the potential to use plasma metabolite profiling to differentiate between vacci

SUBMITTER: Gray DW 

PROVIDER: S-EPMC5886402 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature