P53 is required for brain growth but is dispensable for resistance to nutrient restriction during Drosophila larval development.

ABSTRACT:

Background

Animal growth is influenced by the genetic background and the environmental circumstances. How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a transcription factor that commands the cellular response to different types of stresses. In adult Drosophila melanogaster, p53 regulates the metabolic adaptation to nutrient restriction that supports fly viability. Furthermore, the larval brain is protected from nutrient restriction in a phenomenon called 'brain sparing'. Therefore, we hypothesised that p53 may regulate brain growth and show a protective role over brain development under nutrient restriction.

Results

Here, we studied the function of p53 during brain growth in normal conditions and in animals subjec

SUBMITTER: Contreras EG 

PROVIDER: S-EPMC5886404 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature