Xome-Blender: A novel cancer genome simulator.

ABSTRACT: The adoption of next generation sequencing based methods in cancer research allowed for the investigation of the complex genetic structure of tumor samples. In the last few years, considerable importance was given to the research of somatic variants and several computational approaches were developed for this purpose. Despite continuous improvements to these programs, the validation of their results it's a hard challenge due to multiple sources of error. To overcome this drawback different simulation approaches are used to generate synthetic samples but they are often based on the addition of artificial mutations that mimic the complexity of genomic variations. For these reasons, we developed a novel software, Xome-Blender, that generates synthetic cancer genomes with user defined features

SUBMITTER: Semeraro R 

PROVIDER: S-EPMC5886411 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature