Trends in congenital anomalies in Europe from 1980 to 2012.

ABSTRACT:

Background

Surveillance of congenital anomalies is important to identify potential teratogens.

Methods

This study analysed the prevalence of 61 congenital anomaly subgroups (excluding chromosomal) in 25 population-based EUROCAT registries (1980-2012). Live births, fetal deaths and terminations of pregnancy for fetal anomaly were analysed with multilevel random-effects Poisson regression models.

Results

Seventeen anomaly subgroups had statistically significant trends from 2003-2012; 12 increasing and 5 decreasing.

Conclusions

The annual increasing prevalence of severe congenital heart defects, single ventricle, atrioventricular septal defects and tetralogy of Fallot of 1.4% (95% CI: 0.7% to 2.0%), 4.6% (1.0% to 8.2%), 3.4% (1.3% to 5.5%) and 4.1% (2.4% to 5.7%)

SUBMITTER: Morris JK 

PROVIDER: S-EPMC5886482 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature