Streptococcal M protein promotes IL-10 production by cGAS-independent activation of the STING signaling pathway.

ABSTRACT: From an evolutionary point of view a pathogen might benefit from regulating the inflammatory response, both in order to facilitate establishment of colonization and to avoid life-threatening host manifestations, such as septic shock. In agreement with this notion Streptococcus pyogenes exploits type I IFN-signaling to limit detrimental inflammation in infected mice, but the host-pathogen interactions and mechanisms responsible for induction of the type I IFN response have remained unknown. Here we used a macrophage infection model and report that S. pyogenes induces anti-inflammatory IL-10 in an M protein-dependent manner, a function that was mapped to the B- and C-repeat regions of the M5 protein. Intriguingly, IL-10 was produced downstream of type I IFN-signaling, and production of type

SUBMITTER: Movert E 

PROVIDER: S-EPMC5886698 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature