Medication Profiles of Patients with Cognitive Impairment and High Anticholinergic Burden.

ABSTRACT: BACKGROUND:Drugs with anticholinergic properties are considered potentially inappropriate in patients with cognitive impairment because harms-including delirium, falls, and fractures-may outweigh benefits. OBJECTIVE:To highlight opportunities to improve clinical decision making and care for patients with cognitive impairment and multiple chronic conditions, we identified distinct subgroups of patients with mild cognitive impairment (MCI) and dementia who had high cumulative anticholinergic burden and specific patterns of anticholinergic use. PATIENTS AND METHODS:We conducted a retrospective cohort study in a not-for-profit, integrated delivery system. Participants included community-dwelling adults aged 65 years and older (n = 13,627) with MCI or dementia and at least two other chronic dis

SUBMITTER: Green AR 

PROVIDER: S-EPMC5886812 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature