Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis.

ABSTRACT:

Background

Cardiac fibrosis (CF) is associated with increased ventricular stiffness and diastolic dysfunction and is an independent predictor of long-term clinical outcomes of patients with heart failure (HF). We previously showed that the matricellular CCN5 protein is cardioprotective via its ability to inhibit CF and preserve cardiac contractility.

Objectives

This study examined the role of CCN5 in human heart failure and tested whether CCN5 can reverse established CF in an experimental model of HF induced by pressure overload.

Methods

Human hearts were obtained from patients with end-stage heart failure. Extensive CF was induced by applying transverse aortic constriction for 8 weeks, which was followed by adeno-associated virus-mediated transfer of CCN5 to the hear

SUBMITTER: Jeong D 

PROVIDER: S-EPMC5887128 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature