Mitotic and Meiotic Functions for the SUMOylation Pathway in the Caenorhabditis elegans Germline.

ABSTRACT: Meiosis is a highly regulated process, partly due to the need to break and then repair DNA as part of the meiotic program. Post-translational modifications are widely used during meiotic events to regulate steps such as protein complex formation, checkpoint activation, and protein attenuation. In this paper, we investigate how proteins that are obligatory components of the SUMO (small ubiquitin-like modifier) pathway, one such post-translational modification, affect the Caenorhabditis elegans germline. We show that UBC-9, the E2 conjugation enzyme, and the C. elegans homolog of SUMO, SMO-1, localize to germline nuclei throughout prophase I. Mutant analysis of smo-1 and ubc-9 revealed increased recombination intermediates throughout the germline, originating duri

SUBMITTER: Reichman R 

PROVIDER: S-EPMC5887140 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature