Detecting Polygenic Adaptation in Admixture Graphs.

ABSTRACT: An open question in human evolution is the importance of polygenic adaptation: adaptive changes in the mean of a multifactorial trait due to shifts in allele frequencies across many loci. In recent years, several methods have been developed to detect polygenic adaptation using loci identified in genome-wide association studies (GWAS). Though powerful, these methods suffer from limited interpretability: they can detect which sets of populations have evidence for polygenic adaptation, but are unable to reveal where in the history of multiple populations these processes occurred. To address this, we created a method to detect polygenic adaptation in an admixture graph, which is a representation of the historical divergences and admixture events relating different populations through time. We

SUBMITTER: Racimo F 

PROVIDER: S-EPMC5887149 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature