Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss.

ABSTRACT:

Objective

The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history.

Results

During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p > 0.05), gestational period (p > 0.05), geographical region (p > 0.05) and menstrual history (p > 0.05). However, significant association was seen between MTHFR C677T polymorphism and number of losses (p < 0.05), concluding that the risk of the polymorphism increased with the increase in number of losses. Significant variation in the MTHFR C677T genotype with number of losses among RPL coup

SUBMITTER: Sah AK 

PROVIDER: S-EPMC5887178 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature