Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women.

ABSTRACT:

Background

The identification of variants in the nicotinic acetylcholine receptor (nAChR) subunit genes associated with smoking phenotypes are increasingly important for prevention and treatment of nicotine dependence. In the context of personalized medicine, the aims of this study were to evaluate whether cholinergic receptor nicotinic alpha 2 (CHRNA2), cholinergic receptor nicotinic alpha 3 (CHRNA3), cholinergic receptor nicotinic alpha 5 (CHRNA5) and cholinergic receptor nicotinic beta 3 (CHRNB3) polymorphisms were associated with nicotine dependence severity, and to investigate possible pharmacogenetics markers of smoking cessation treatment.

Methods

This study cohort enrolled 1049 smoking patients who received pharmacological treatment (varenicline, varenicline plus bup

SUBMITTER: Tomaz PRX 

PROVIDER: S-EPMC5887212 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature