INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression.

ABSTRACT:

Background

Innate immunity activator (INAVA) has been shown to be elevated in lung adenocarcinoma. However, its expression pattern and function in papillary thyroid cancer (PTC) are unknown. This study aimed to identify the clinical, biological, and mechanistic impacts of INAVA on PTC.

Methods

Using The Cancer Genome Atlas dataset, real time PCR, and immunohistochemistry, the expression of INAVA in PTC was analyzed. Gain- and loss-of-function assays were performed to investigate the role of INAVA in PTC cell invasion, migration, and metastasis. We explored the molecular mechanisms underlying the roles of INAVA in PTC cells using transcriptome resequencing, real time PCR, western blotting and immunohistochemistry.

Results

We found that INAVA expression was significantl

SUBMITTER: Guan H 

PROVIDER: S-EPMC5887255 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature