Giardia secretome highlights secreted tenascins as a key component of pathogenesis.

ABSTRACT:

Background

Giardia is a protozoan parasite of public health relevance that causes gastroenteritis in a wide range of hosts. Two genetically distinct lineages (assemblages A and B) are responsible for the human disease. Although it is clear that differences in virulence occur, the pathogenesis and virulence of Giardia remain poorly understood.

Results

The genome of Giardia is believed to contain open reading frames that could encode as many as 6000 proteins. By successfully applying quantitative proteomic analyses to the whole parasite and to the supernatants derived from parasite culture of assemblages A and B, we confirm expression of ∼1600 proteins from each assemblage, the vast majority of which are common to both lineages. To look for signature enrichment of secreted pro

SUBMITTER: Dubourg A 

PROVIDER: S-EPMC5887430 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature