13.4 CANNABINOID RECEPTOR GENE POLYMORPHISMS AND COGNITIVE PERFORMANCE IN PATIENTS WITH SCHIZOPHRENIA

ABSTRACT: Abstract

Background

Cognition is a major determinant of functioning in patients with schizophrenia. There is evidence that the endocannabinoid system influences cognition in human subjects, and participates in the pathophysiology of schizophrenia. In a previous study, we have shown that the expression of cannabinoid receptors (CB1R and CB2R) on peripheral lymphocytes is inversely correlated with performance in the Brief Assessment of Cognition in Schizophrenia (BACS), in patients with schizophrenia. Recently, CBRs polymorphisms have been associated with an increased risk for schizophrenia, structural changes in the central nervous systems and in cognitive performance of the patients. The aim of the present study was to investigate the association between CBRs polymorphisms and cog

SUBMITTER: Salgado J 

PROVIDER: S-EPMC5887465 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature