HO-1^hi patrolling monocytes protect against vaso-occlusion in sickle cell disease.

ABSTRACT: Patients with sickle cell disease (SCD) suffer from intravascular hemolysis associated with vascular injury and dysfunction in mouse models, and painful vaso-occlusive crisis (VOC) involving increased attachment of sickle erythrocytes and activated leukocytes to damaged vascular endothelium. Patrolling monocytes, which normally scavenge damaged cells and debris from the vasculature, express higher levels of anti-inflammatory heme oxygenase 1 (HO-1), a heme degrading enzyme. Here, we show that HO-1-expressing patrolling monocytes protect SCD vasculature from ongoing hemolytic insult and vaso-occlusion. We found that a mean 37% of patrolling monocytes from SCD patients express very high levels of HO-1 (HO-1^hi) vs 6% in healthy controls and demonstrated that HO-1^hi expre

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5887768 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature