Proof of concept: liver splitting during normothermic machine perfusion.

ABSTRACT:

Introduction

Despite utilizing extended criteria donors, there remains a shortage of livers for transplantation. No data exists on splitting donor livers with concurrent NMP-L.

Methods

A liver recovered from a donor after circulatory death was subjected to NMP-L using a red cell based fluid. During NMP-L, a 'classical' left lateral + right trisegmentectomy split was performed using an integrated bipolar/ultrasonic device. After splitting, blood flow was confirmed using Doppler ultrasound in each lobe.

Results

Prior to splitting, flow rates were maintained physiologically. Lactate decreased from 13.9 to 3.0 mmol/L. Lactate before and after splitting were similar in the hepatic arteries, portal veins and IVC. Doppler ultrasound demonstrated arterial and venous waveforms

SUBMITTER: Stephenson BTF 

PROVIDER: S-EPMC5887957 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature