Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors.

ABSTRACT:

Background

A significant proportion of donation after circulatory death (DCD) kidneys are declined for transplantation because of concerns over their quality. Ex vivo normothermic machine perfusion (NMP) provides a unique opportunity to assess the quality of a kidney and determine its suitability for transplantation.

Methods

In phase 1 of this study, declined human DCD kidneys underwent NMP assessment for 60 min. Kidneys were graded 1-5 using a quality assessment score (QAS) based on macroscopic perfusion, renal blood flow and urine output during NMP. In phase 2 of the study, declined DCD kidneys were assessed by NMP with an intention to transplant them.

Results

In phase 1, 18 of 42 DCD kidneys were declined owing to poor in situ perfusion. After NMP, 28 kidneys had a

SUBMITTER: Hosgood SA 

PROVIDER: S-EPMC5887977 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature