Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine.

ABSTRACT: Background:We previously reported that serotonergic transmission plays an important role in antidepressant effects of ketamine. However, detailed mechanisms have not been elucidated. Among the serotonin receptor subtypes, the serotonin1A receptor in the medial prefrontal cortex has an important role in depression. Here, we investigated the role of the medial prefrontal cortex serotonin1A receptor and its signaling mechanism in the antidepressant effects of ketamine. Methods:The role of serotonin1A receptor-mediated signaling mechanism (phosphoinositide-3 kinase/Akt) in the medial prefrontal cortex was examined in the mouse forced swimming test and western blotting. Results:Ketamine exerted antidepressant effects that lasted for 24 hours, and the sustained antidepressant effects were attenu

SUBMITTER: Fukumoto K 

PROVIDER: S-EPMC5888010 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature