Interaction of a dinoflagellate neurotoxin with voltage-activated ion channels in a marine diatom.

ABSTRACT:

Background

The potent neurotoxins produced by the harmful algal bloom species Karenia brevis are activators of sodium voltage-gated channels (VGC) in animals, resulting in altered channel kinetics and membrane hyperexcitability. Recent biophysical and genomic evidence supports widespread presence of homologous sodium (Na⁺) and calcium (Ca²⁺) permeable VGCs in unicellular algae, including marine phytoplankton. We therefore hypothesized that VGCs of these phytoplankton may be an allelopathic target for waterborne neurotoxins produced by K. brevis blooms that could lead to ion channel dysfunction and disruption of signaling in a similar manner to animal Na⁺ VGCs.

Methods

We examined the interaction of brevetoxin-3 (PbTx-3), a K.

SUBMITTER: Kitchen SA 

PROVIDER: S-EPMC5888156 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature