CXCL4 is a novel inducer of human Th17 cells and correlates with IL-17 and IL-22 in psoriatic arthritis.

ABSTRACT: CXCL4 regulates multiple facets of the immune response and is highly upregulated in various Th17-associated rheumatic diseases. However, whether CXCL4 plays a direct role in the induction of IL-17 production by human CD4⁺ T cells is currently unclear. Here, we demonstrated that CXCL4 induced human CD4⁺ T cells to secrete IL-17 that co-expressed IFN-γ and IL-22, and differentiated naïve CD4⁺ T cells to become Th17-cytokine producing cells. In a co-culture system of human CD4⁺ T cells with monocytes or myeloid dendritic cells, CXCL4 induced IL-17 production upon triggering by superantigen. Moreover, when monocyte-derived dendritic cells were differentiated in the presence of CXCL4, they orchestrated increased levels of IL-17, IFN-γ, and proliferati

SUBMITTER: Affandi AJ 

PROVIDER: S-EPMC5888178 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature