Impact of differing glucose-lowering regimens on the pattern of association between glucose control and survival.

ABSTRACT:

Aims

To characterize survival in relation to achieved glycated haemoglobin (HbA1c) level within alternative glucose-lowering regimens with differing risks of hypoglycaemia.

Methods

Data were extracted from the UK Clinical Practice Research Datalink and the corresponding Hospital Episode Statistics. Patients with type 2 diabetes prescribed glucose-lowering therapy in monotherapy or dual therapy with metformin between 2004 and 2013 were identified. Risk of all-cause mortality within treatment cohorts was evaluated using the Cox proportional hazards model, introducing mean HbA1c as a quarterly updated, time-dependent covariable.

Results

There were 6646 deaths in a total follow-up period of 374 591 years. Survival for lower (<7%) vs moderate HbA1c levels (≥7%, <8.5%) diff

SUBMITTER: Currie CJ 

PROVIDER: S-EPMC5888185 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature