Reversibility of myocardial metabolism and remodelling in morbidly obese patients 6 months after bariatric surgery.

ABSTRACT:

Aims

To study myocardial substrate uptake, structure and function, before and after bariatric surgery, to clarify the interaction between myocardial metabolism and cardiac remodelling in morbid obesity.

Methods

We studied 46 obese patients (age 44 ± 10 years, body mass index [BMI] 42 ± 4 kg/m² ), including 18 with type 2 diabetes (T2D) before and 6 months after bariatric surgery and 25 healthy age-matched control group subjects. Myocardial fasting free fatty acid uptake (MFAU) and insulin-stimulated myocardial glucose uptake (MGU) were measured using positron-emission tomography. Myocardial structure and function, and myocardial triglyceride content (MTGC) and intrathoracic fat were measured using magnetic resonance imaging and magnetic resonance spectroscopy.

SUBMITTER: Hannukainen JC 

PROVIDER: S-EPMC5888194 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature