Adenosine receptors differentially regulate type 2 cytokine production by IL-33-activated bone marrow cells, ILC2s, and macrophages.

ABSTRACT: Group 2 innate lymphoid cells (ILC2s) represent a rapid source of type 2 cytokines, such as IL-5 and IL-13, and play an important role in orchestrating type 2 immune response. Adenosine is an endogenous purine nucleoside, a catabolite of ATP that binds and activates ≥1 of 4 transmembrane G protein-coupled cell-surface adenosine receptors (ARs)-A₁, A_2A, A_2B, and A₃. Here, we studied the role of ARs in the regulation of cytokine production by ILC2s. We found that A_2BARs suppress the production of both IL-5 and IL-13 by ILC2s, whereas A_2AARs augment IL-5 production and fail to affect IL-13 release. Combined stimulation of all ARs led to the suppression of both IL-5 and IL-13 production, which indicated that A_2BARs do

SUBMITTER: Csoka B 

PROVIDER: S-EPMC5888397 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature