Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC5888401 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Wang Lijun L Iorio Caterina C Yan Kevin K Yang Howard H Takeshita Sunao S Kang Sumin S Neel Benjamin G BG Yang Wentian W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20180104 2
Activation of the RAS/ERK and its downstream signaling components is essential for growth factor-induced cell survival, proliferation, and differentiation. The Src homology-2 domain containing protein tyrosine phosphatase 2 (SHP2), encoded by protein tyrosine phosphatase, non-receptor type 11 ( Ptpn11), is a positive mediator required for most, if not all, receptor tyrosine kinase-evoked RAS/ERK activation, but differentially regulates the PI3K/AKT signaling cascade in various cellular contexts. ...[more]