20.3 OPEN CHROMATIN ANALYSES INFORM FUNCTIONAL NONCODING GWAS VARIANTS IN HIPSC MODEL OF MENTAL DISORDERS

ABSTRACT: Abstract

Background

Neuropsychiatric disorders, including schizophrenia (SZ), afflict a significant fraction of the population. Recent genome-wide association studies (GWAS) under the framework of the Psychiatric Genomics Consortium (PGC), along with large-scale sequencing efforts, have identified a plethora of disease risk loci with common and/or rare risk variants. Translating these exciting genomic findings into causation and disease biology offers the promise of developing more tailored therapies in psychiatry. However, understanding the disease biology underlying most GWAS findings remains challenging: (1) The paucity of disease-relevant biological materials for assaying molecular and cellular phenotypes associated with risk loci; (2) Most disease variants lie within poorly-a

SUBMITTER: Duan J 

PROVIDER: S-EPMC5888490 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature