Glutathione, the Major Redox Regulator, in the Prefrontal Cortex of Individuals at Clinical High Risk for Psychosis.

ABSTRACT:

Introduction

Oxidative stress and glutathione dysregulation have been implicated in the etiology of schizophrenia. To date, most in vivo studies have investigated alterations in cerebral glutathione levels in patients in which the disorder is already established; however, whether oxidative stress actually predates the onset of psychosis remains unknown. In the current study, we investigated cerebral glutathione levels of antipsychotic-naïve individuals at clinical high risk for psychosis. As exploratory analyses, we also investigated the associations between cerebral glutathione levels and peripheral glutathione peroxidase activity and clinical and neuropsychological measures.

Methods

Glutathione levels were measured in the medial prefrontal cortex of 30 clinical high risk (

SUBMITTER: Da Silva T 

PROVIDER: S-EPMC5888512 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature