Quantification of Torque Teno Virus and Epstein-Barr Virus Is of Limited Value for Predicting the Net State of Immunosuppression After Lung Transplantation.

ABSTRACT:

Background

Major hurdles for survival after lung transplantation are rejections and infectious complications. Adequate methods for monitoring immune suppression status are lacking. Here, we evaluated quantification of torque teno virus (TTV) and Epstein-Barr virus (EBV) as biomarkers for defining the net state of immunosuppression in lung-transplanted patients.

Methods

This prospective single-center study included 98 patients followed for 2 years after transplantation. Bacterial infections, fungal infections, viral respiratory infections (VRTI), cytomegalovirus (CMV) viremia, and acute rejections, as well as TTV and EBV levels, were monitored.

Results

The levels of torque teno virus DNA increased rapidly after transplantation, likely due to immunosuppressive treatment

SUBMITTER: Norden R 

PROVIDER: S-EPMC5888719 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature