F192. SYSTEMATIC META-ANALYSIS IDENTIFIES FIVE NOVEL ASSOCIATION LOCI FOR SCHIZOPHRENIA

ABSTRACT: Abstract

Background

Schizophrenia is a highly heritable psychiatric disorder. In the past 30 years, thousands of case-control and family-designed association studies have examined candidate genes for schizophrenia. To assist the field in interpreting this large volume of gene-association studies, the online SzGene database was created and included meta analyses for 287 polymorphisms at the time of its final update in 2010. However, since then more than one-thousand new gene-association studies in schizophrenia have been conducted. As such, we have conducted an updated systematic review and meta-analysis of all gene-association studies in schizophrenia published before March 2017.

Methods

Studies published between January 2010 and March 2017 were identified using a customi

SUBMITTER: Liu C 

PROVIDER: S-EPMC5888745 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature