Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis.

ABSTRACT:

Background

This study examines the effect of interstitial inflammation and interstitial fibrosis and tubular atrophy on renal survival in lupus nephritis.

Methods

Baseline characteristics, initial (n = 301) and repeat biopsies (n = 94) and clinical outcomes for patients with biopsy-proven lupus nephritis from 1998 to 2014 were retrospectively collected from the medical record. Clinical and morphologic variables were evaluated using a Cox proportional hazards model and multiple imputation to address missing data. Renal survival was defined as the time from initial biopsy to end-stage renal disease [estimated glomerular filtration rate (eGFR) <15 mL/min/1.73 m²], dialysis or transplant.

Results

A total of 218 patients had follow-up and Class IV

SUBMITTER: Wilson PC 

PROVIDER: S-EPMC5888814 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature