Generalizing Randomized Clinical Trial Results: Implementation and Challenges Related to Missing Data in the Target Population.

ABSTRACT: Statins are indicated in patients with elevated levels of high-sensitivity C-reactive protein and normal low-density lipoprotein cholesterol based on results of the multicountry trial, Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) (2003-2008), but the benefit in real-world populations remains unknown. We sought to generalize JUPITER results to trial-eligible population using data from the UK Clinical Practice Research Datalink (CPRD), 2001-2014. We multiply imputed missing baseline characteristics for the CPRD population and selected the trial-eligible participants as the target population based on observed and imputed values. Trial participants were weighted to be representative of the CPRD population (n = 383,418) based on ind

SUBMITTER: Hong JL 

PROVIDER: S-EPMC5888945 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature