Schizophrenia polygenic risk score predicts mnemonic hippocampal activity.

ABSTRACT: The use of polygenic risk scores has become a practical translational approach to investigating the complex genetic architecture of schizophrenia, but the link between polygenic risk scores and pathophysiological components of this disorder has been the subject of limited research. We investigated in healthy volunteers whether schizophrenia polygenic risk score predicts hippocampal activity during simple memory encoding, which has been proposed as a risk-associated intermediate phenotype of schizophrenia. We analysed the relationship between polygenic risk scores and hippocampal activity in a discovery sample of 191 unrelated healthy volunteers from the USA and in two independent replication samples of 76 and 137 healthy unrelated participants from Europe and the USA, respectively. Polygen

SUBMITTER: Chen Q 

PROVIDER: S-EPMC5888989 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature