Genotype-Specific Measles Transmissibility: A Branching Process Analysis.

ABSTRACT:

Background

Substantial heterogeneity in measles outbreak sizes may be due to genotype-specific transmissibility. Using a branching process analysis, we characterize differences in measles transmission by estimating the association between genotype and the reproduction number R among postelimination California measles cases during 2000-2015 (400 cases, 165 outbreaks).

Methods

Assuming a negative binomial secondary case distribution, we fit a branching process model to the distribution of outbreak sizes using maximum likelihood and estimated the reproduction number R for a multigenotype model.

Results

Genotype B3 is found to be significantly more transmissible than other genotypes (P = .01) with an R of 0.64 (95% confidence interval [CI], .48-.71), while the R for all o

SUBMITTER: Ackley SF 

PROVIDER: S-EPMC5889020 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature