Antidepressant medication use, depression, and the risk of preeclampsia.

ABSTRACT:

Objective

To assess the effects of depression and antidepressant medication use during pregnancy on the risk of preeclampsia.

Methods

We conducted a retrospective, population-based cohort study that linked automated clinical and pharmacy databases including comprehensive electronic medical records of 21,589 pregnant Kaiser Permanente Northern California members between 2010 and 2012.

Results

The overall risk of preeclampsia was 4.5%. The timing of antidepressant medication exposure was an important factor. A significant increase in the risk of preeclampsia emerged for women with a depression diagnosis who took antidepressant medications during the second trimester compared to women with untreated depression (adjusted relative risk [aRR]: 1.6, 95% CI: 1.06, 2.39) and t

SUBMITTER: Avalos LA 

PROVIDER: S-EPMC5889130 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature