A novel MDSC-induced PD-1^-PD-L1⁺ B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties.

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells that suppress T-cell activity in a tumor microenvironment. However, the suppressive function of MDSCs on B cells and its underlying mechanism remain unclear. Here, we show that in 4T1 breast cancer mice, a significantly increased number of MDSCs, in parallel with splenic B cells, are accumulated when compared to normal mice. In the presence of MDSCs, the surface molecules of B cells are remolded, with checkpoint-related molecules such as PD-1 and PD-L1 changing prominently. MDSCs also emerge as vital regulators in B-cell immune functions such as proliferation, apoptosis and the abilities to secrete antibodies and cytokines. Our study further identifies that MDSCs can transform normal B cells to a subtype of

SUBMITTER: Shen M 

PROVIDER: S-EPMC5889195 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature