Modulation of CD8⁺ memory stem T cell activity and glycogen synthase kinase 3β inhibition enhances anti-tumoral immunity in gastric cancer.

ABSTRACT: The potential contributions of CD8⁺ memory stem T cells to anti-tumor immunity and immunotherapy responses in gastric cancer has not been demonstrated. We found that CD8⁺ memory stem T cell frequencies were increased in the peripheral blood of gastric cancer patients compared to healthy donors and declined in frequency with disease progression. Despite minimal in vitro cytotoxic activity, the adoptive transfer of CD8⁺ memory stem T cells into Rag1^-/- tumor bearing mice enhanced tumor regression compared to CD8⁺ central or effector memory T cell counterparts. This effect was associated with an increase in splenic, draining lymph node and tumor infiltrating CD8⁺ T cell numbers and the development of an altered CD8⁺

SUBMITTER: Zhang JY 

PROVIDER: S-EPMC5889281 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature