Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells.

ABSTRACT: The extracellular matrix protein biglycan (BGN) has oncogenic or tumor suppressive potential depending on the cellular origin. HER-2/neu overexpression in murine fibroblasts and human model systems is inversely correlated with BGN expression. Upon its restoration BGN^high HER-2/neu⁺ fibroblasts were less tumorigenic in immune competent mice when compared to BGN^low/neg HER-2/neu⁺ cells, which was associated with enhanced immune cell responses and higher frequencies of immune effector cells in tumors and peripheral blood. The increased immunogenicity of BGN^high HER-2/neu⁺ fibroblasts appears to be due to upregulated MHC class I surface antigens and reduced expression levels of transforming growth factor (TGF)-β isoforms and the

SUBMITTER: Subbarayan K 

PROVIDER: S-EPMC5889282 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature