Ontology highlight
ABSTRACT:
SUBMITTER: Charlton J
PROVIDER: S-EPMC5889353 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20180312 4
Cytosine methylation is widespread among organisms and essential for mammalian development. In line with early postulations of an epigenetic role in gene regulation, symmetric CpG methylation can be mitotically propagated over many generations with extraordinarily high fidelity. Here, we combine BrdU labeling and immunoprecipitation with genome-wide bisulfite sequencing to explore the inheritance of cytosine methylation onto newly replicated DNA in human cells. Globally, we observe a pronounced ...[more]