Coalescent framework for prokaryotes undergoing interspecific homologous recombination.

ABSTRACT: Coalescent process for prokaryote species is theoretically considered. Prokaryotes undergo homologous recombination with individuals of the same species (intraspecific recombination) and with individuals of other species (interspecific recombination). This work particularly focuses on interspecific recombination because intraspecific recombination has been well incorporated in coalescent framework. We present a simulation framework for generating SNP (single-nucleotide polymorphism) patterns that allows external DNA integration into host genome from other species. Using this simulation tool, msPro, we observed that the joint processes of intra- and interspecific recombination generate complex SNP patterns. The direct effect of interspecific recombination includes increased polymorphism. Be

SUBMITTER: Akita T 

PROVIDER: S-EPMC5889408 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature