Association of EGLN1 genetic polymorphisms with SpO₂ responses to acute hypobaric hypoxia in a Japanese cohort.

ABSTRACT:

Background

Recent studies have explored various genetic and physiological factors related to high-altitude adaptation in highlander populations. However, the effects of single nucleotide polymorphisms (SNPs), influencing such adaptation, on physiological responses to hypobaric hypoxia have not been examined in lowlanders with lowlander ancestry. Thus, we aimed to investigate the association between SNPs around the EGLN1 genomic region, possibly involved in high-altitude adaptation, and physiological changes to hypobaric hypoxia exposure in a cohort of Japanese lowlanders.

Methods

Physiological data were obtained from 46 healthy Japanese male students under different atmospheric pressure conditions (equivalent to sea level and altitudes of 2500 and 4000 m). Genotypes of seven

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC5889538 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature