A nutrient-dependent division antagonist is regulated post-translationally by the Clp proteases in Bacillus subtilis.

ABSTRACT:

Background

Changes in nutrient availability have dramatic and well-defined impacts on both transcription and translation in bacterial cells. At the same time, the role of post-translational control in adaptation to nutrient-poor environments is poorly understood. Previous studies demonstrate the ability of the glucosyltransferase UgtP to influence cell size in response to nutrient availability. Under nutrient-rich medium, interactions with its substrate UDP-glucose promote interactions between UgtP and the tubulin-like cell division protein FtsZ in Bacillus subtilis, inhibiting maturation of the cytokinetic ring and increasing cell size. In nutrient-poor medium, reductions in UDP-glucose availability favor UgtP oligomerization, sequestering it from FtsZ and allowing division to occ

SUBMITTER: Hill NS 

PROVIDER: S-EPMC5889556 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature