COZOID: contact zone identifier for visual analysis of protein-protein interactions.

ABSTRACT:

Background

Studying the patterns of protein-protein interactions (PPIs) is fundamental for understanding the structure and function of protein complexes. The exploration of the vast space of possible mutual configurations of interacting proteins and their contact zones is very time consuming and requires the proteomic expert knowledge.

Results

In this paper, we propose a novel tool containing a set of visual abstraction techniques for the guided exploration of PPI configuration space. It helps proteomic experts to select the most relevant configurations and explore their contact zones at different levels of detail. The system integrates a set of methods that follow and support the workflow of proteomics experts. The first visual abstraction method, the Matrix view, is based

SUBMITTER: Furmanova K 

PROVIDER: S-EPMC5889581 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature